Procaine and procainamide
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چکیده
منابع مشابه
Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.
Secreted Wingless type (Wnt) ligands have previously been shown to be involved in tumor developmental processes and oncogenesis. Aberrant promoter methylation of Wnt inhibitory factor-1 (WIF-1) is a fundamental mechanism of epigenetic silencing in human cancers. Procaine, a local anesthetic drug, and procainamide, a drug for the treatment of cardiac arrhythmias, have been reported as inhibitors...
متن کاملThe action of procaine and procaine amide on the heart.
The depressant action of procaine on the heart muscle has been the subject of several clinical and experimental studies (Wiggers and Wegria, 1940; Burstein, 1946; Uhley and Wilburne, 1948; Schaffer et al., 1950). Procaine was found useful in the treatment of cardiac arrhythmias occurring in anesthetized patients during cardiac surgery. However, its usefulness in the management of clinical arrhy...
متن کاملEffects of Procainamide
Electrophysiological effects of 750 mg i.v. procainamide were studied in 14 patients with dual pathway atrioventricular (A-V) nodal re-entrant paroxysmal tachycardia (PSVT). All patients utilized an A-V nodal slow pathway for antegrade and an A-V nodal fast pathway for retrograde conduction during PSVT. In all 14 patients, procainamide depressed retrograde fast pathway conduction, manifest by i...
متن کاملTransitory procaine-induced Parkinsonism.
A case of prolonged, though reversible procaine-induced Parkinsonism treated with l-dopa and trihexyphenidyl (Artane-Sustets) is reported. A pathophysiological explanation is discussed on the basis of recent theories concerning the transmitter systems of the basal ganglia.
متن کاملProcaine in malignant hyperpyrexia.
The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increase...
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ژورنال
عنوان ژورنال: Heart
سال: 1992
ISSN: 1355-6037
DOI: 10.1136/hrt.67.2.143